Mercedes-AMG was the official engine supplier for the second oldest and most successful F1 team by Grand Prix wins, McLaren Racing from 1995-2014. In 2013 it was announced that after the last year with Mercedes contract with McLaren, Mercedes would be dropped and be replaced by Honda, with whom McLaren had world championship wins in the past together.

Mercedes have since gone on to buy their own Formula 1 team, buying the former Honda Racing F1 team, Brawn GP, and turning it into Mercedes F1 in 2010. Despite a slow start, in 2012 the team began to show progress and rise to the front of the Grid with their first win coming from driver Nico Rosberg at the 2012 Chinese Grand Prix, before showing further progress again in 2013, when the team signed Lewis Hamilton from McLaren to replace the retiring Michael Schumacher. Hamilton's first win for the team came at the 2013 Hungarian Grand Prix.

In 2014 the team won the Formula One World Constructors Title, with Driver Lewis Hamilton going on to win the Drivers Title. In 2015 the team won their second successive World Constructors Title and drivers title with Lewis Hamilton once again.